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2024, Vol: 14, Issue: 4
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Research Article 


Monospecific antibody against Bordetella pertussis Adenylate Cyclase protects from Pertussis

Yasmeen Faiz Kazi, Qurban Hussain.


Cited By:1

Abstract
Objectives: Acellular pertussis vaccines has been largely accepted world-wide however, there are reports about limited antibody response against these vaccines suggesting that multiple antigens should be included in acellular vaccines to attain full protection. The aim of present study was to evaluate the role of Bordetella pertussis adenylate cyclase as a protective antigen.
Materials and methods: Highly mono-specific antibody against adenylate cyclase (AC) was raised in rabbits using nitrocellulose bound adenylate cyclase and the specificity was assessed by immuoblotting. B.pertussis 18-323, was incubated with the mono-specific serum and without serum as a control. Mice were challenged intra-nasally and pathophysiolgical responses were recorded.
Results: The production of B.pertussis adenylate cyclase monospecific antibody that successfully recognized on immunoblot and gave protection against fatality (p< 0.01) and lung consolidation (p <0.01). Mouse weight gain showed significant difference (p< 0.05).
Conclusion: These preliminary results highlight the role of the B.pertussis adenylate cyclase as a potential pertussis vaccine candidate. B.pertussis AC exhibited significant protection against pertussis in murine model. J Microbiol Infect Dis 2012; 2(2): 37-43

Key words: Pertussis; monospecific; antibody; passive-protection


 
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Pubmed Style

Kazi YF, Hussain Q. Monospecific antibody against Bordetella pertussis Adenylate Cyclase protects from Pertussis. J Microbiol Infect Dis. 2012; 2(2): 36-43 . doi:10.5799/jmid2012.02.0040

Web Style

Kazi YF, Hussain Q. Monospecific antibody against Bordetella pertussis Adenylate Cyclase protects from Pertussis. https://www.jmidonline.org/?mno=302657192 [Access: January 09, 2025]. doi:10.5799/jmid2012.02.0040

AMA (American Medical Association) Style

Kazi YF, Hussain Q. Monospecific antibody against Bordetella pertussis Adenylate Cyclase protects from Pertussis. J Microbiol Infect Dis. 2012; 2(2): 36-43 . doi:10.5799/jmid2012.02.0040


Vancouver/ICMJE Style

Kazi YF, Hussain Q. Monospecific antibody against Bordetella pertussis Adenylate Cyclase protects from Pertussis. J Microbiol Infect Dis. (2012), [cited January 09, 2025]; 2(2): 36-43 . doi:10.5799/jmid2012.02.0040


Harvard Style

Kazi, Y. F. & Hussain, . Q. (2012) Monospecific antibody against Bordetella pertussis Adenylate Cyclase protects from Pertussis. J Microbiol Infect Dis, 2 (2), 36-43 . doi:10.5799/jmid2012.02.0040


Turabian Style

Kazi, Yasmeen Faiz, and Qurban Hussain. 2012. Monospecific antibody against Bordetella pertussis Adenylate Cyclase protects from Pertussis. Journal of Microbiology and Infectious Diseases, 2 (2), 36-43 . doi:10.5799/jmid2012.02.0040


Chicago Style

Kazi, Yasmeen Faiz, and Qurban Hussain. "Monospecific antibody against Bordetella pertussis Adenylate Cyclase protects from Pertussis." Journal of Microbiology and Infectious Diseases 2 (2012), 36-43 . doi:10.5799/jmid2012.02.0040


MLA (The Modern Language Association) Style

Kazi, Yasmeen Faiz, and Qurban Hussain. "Monospecific antibody against Bordetella pertussis Adenylate Cyclase protects from Pertussis." Journal of Microbiology and Infectious Diseases 2.2 (2012), 36-43 . Print. doi:10.5799/jmid2012.02.0040


APA (American Psychological Association) Style

Kazi, Y. F. & Hussain, . Q. (2012) Monospecific antibody against Bordetella pertussis Adenylate Cyclase protects from Pertussis. Journal of Microbiology and Infectious Diseases, 2 (2), 36-43 . doi:10.5799/jmid2012.02.0040


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Journal of Microbiology and Infectious Diseases

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