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Research Article 


Evaluation of immune status against hepatitis B in children with thalassemia major in Egypt: A single center study

Hanan H. Soliman, Ibrahim Kabbash A., Mohamed R. El-shanshory, Hala M. Nagy, Said H. Abdou.


Cited By:11

Abstract
Objectives: Thalassemic children with repeated blood transfusion are at higher risk of suffering transfusion related infections including hepatitis B virus (HBV). HBV vaccine immunogenicity in several studies showed variable response rates. The aim of this study is to evaluate the immunogenic effect of hepatitis B vaccine in thalassemic children at different age groups.
Materials and methods: After ethical approval and informed parent consent, 125 diagnosed thalassemic patients were recruited from the Hematology/Oncology Unit, Pediatric Department, Tanta University Hospital. Patient 's transfusion, and vaccination history, clinical data, and blood samples were obtained. Patient 's sera were stored at -20°C till tested for Anti-hepatitis B surface (anti-HBs) by ELISA. Patients with titers <10 IU were tested for HBs-Ag.
Results: Although none of our cases had hepatitis B virus infection, only 20.8% had a protective anti-HBs titer (>10 IU/L). Significantly higher percentage of protected patients (40.1%) were younger than 3 years of age, while age groups above 3years showed a significant trend towards having non protective titers (p=0.003). Anti-HBs titers weren 't correlated to age, ferritin, liver enzymes, and duration of transfusion or number of transfused packs.
Conclusion: Protective Anti-HBs titer was reduced after age of 3 years in our patients. So, we recommend screening of thalassemic patients at age of 3 years to evaluate the need of a booster dose. J Microbiol Infect Dis 2012; 2(2): 44-49

Key words: Thalassemia, HBV, vaccination, immunogenicity


 
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How to Cite this Article
Pubmed Style

Soliman HH, A. IK, El-shanshory MR, Nagy HM, Abdou SH. Evaluation of immune status against hepatitis B in children with thalassemia major in Egypt: A single center study. J Microbiol Infect Dis. 2012; 2(2): 44-49 . doi:10.5799/jmid2012.03.0041

Web Style

Soliman HH, A. IK, El-shanshory MR, Nagy HM, Abdou SH. Evaluation of immune status against hepatitis B in children with thalassemia major in Egypt: A single center study. https://www.jmidonline.org/?mno=302657049 [Access: January 09, 2025]. doi:10.5799/jmid2012.03.0041

AMA (American Medical Association) Style

Soliman HH, A. IK, El-shanshory MR, Nagy HM, Abdou SH. Evaluation of immune status against hepatitis B in children with thalassemia major in Egypt: A single center study. J Microbiol Infect Dis. 2012; 2(2): 44-49 . doi:10.5799/jmid2012.03.0041


Vancouver/ICMJE Style

Soliman HH, A. IK, El-shanshory MR, Nagy HM, Abdou SH. Evaluation of immune status against hepatitis B in children with thalassemia major in Egypt: A single center study. J Microbiol Infect Dis. (2012), [cited January 09, 2025]; 2(2): 44-49 . doi:10.5799/jmid2012.03.0041


Harvard Style

Soliman, H. H., A., . I. K., El-shanshory, . M. R., Nagy, . H. M. & Abdou, . S. H. (2012) Evaluation of immune status against hepatitis B in children with thalassemia major in Egypt: A single center study. J Microbiol Infect Dis, 2 (2), 44-49 . doi:10.5799/jmid2012.03.0041


Turabian Style

Soliman, Hanan H., Ibrahim Kabbash A., Mohamed R. El-shanshory, Hala M. Nagy, and Said H. Abdou. 2012. Evaluation of immune status against hepatitis B in children with thalassemia major in Egypt: A single center study. Journal of Microbiology and Infectious Diseases, 2 (2), 44-49 . doi:10.5799/jmid2012.03.0041


Chicago Style

Soliman, Hanan H., Ibrahim Kabbash A., Mohamed R. El-shanshory, Hala M. Nagy, and Said H. Abdou. "Evaluation of immune status against hepatitis B in children with thalassemia major in Egypt: A single center study." Journal of Microbiology and Infectious Diseases 2 (2012), 44-49 . doi:10.5799/jmid2012.03.0041


MLA (The Modern Language Association) Style

Soliman, Hanan H., Ibrahim Kabbash A., Mohamed R. El-shanshory, Hala M. Nagy, and Said H. Abdou. "Evaluation of immune status against hepatitis B in children with thalassemia major in Egypt: A single center study." Journal of Microbiology and Infectious Diseases 2.2 (2012), 44-49 . Print. doi:10.5799/jmid2012.03.0041


APA (American Psychological Association) Style

Soliman, H. H., A., . I. K., El-shanshory, . M. R., Nagy, . H. M. & Abdou, . S. H. (2012) Evaluation of immune status against hepatitis B in children with thalassemia major in Egypt: A single center study. Journal of Microbiology and Infectious Diseases, 2 (2), 44-49 . doi:10.5799/jmid2012.03.0041


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Journal of Microbiology and Infectious Diseases

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