E-ISSN 2146-9369 | ISSN 2146-3158
 
2024, Vol: 14, Issue: 3
14 / 3Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles

Research Article 


Association of demographic, clinical, laboratory, and radiological characteristics with outcomes of COVID-19 patients: A systematic review and Meta-analysis

Partha Sarathi Biswas, Devosri Sen, Anirban Homchoudhary, Deepika Makkar, Mahima Kapoor, Amandeep Goel.


Cited By:9

Abstract
Objectives: The aim of this meta-analysis was to assess association between a composite clinical outcome (severe infection/ required ICU admission/ death) of COVID-19 pneumonia and demographic, clinical, laboratory and radiological findings of these patients.
Methods: A literature search was conducted using the databases PubMed, Medline, Scopus and Web of Science till July. Relative risk (RRs), standardized mean difference (SMDs) and 95% confidence intervals (CIs) were pooled using random-effects models. We described overall estimates of relevant data of clinical importance from 116,260 COVID-19 pneumonia patients including 19,628 with composite end points from 40 observational studies of 5 countries.
Results: The result showed that male gender (RR=1.24, p <.001), older age (SMD= 3.19, P<.001) especially > 64 years (RR=2.52, P <.001) followed aggravated course. Delayed hospitalization (SMD=.75, p= 0.005), presence of co-morbidity (RR= 1.76, p<.001) and multiple co-morbidities (RR=1.50, p<.001) were associated with higher risk of fatal course. Pooled data reported significantly high neutrophil-lymphocyte ratio (SMD=10.79, p<.001), low lymphocyte-to-C-reactive protein ratio (SMD=-3.89, p<.001), low platelet count (SMD=-1.622, p<.001), prolonged prothrombin time (SMD=0.98, p<.001), high lactate dehydrogenase (SMD=6.260, p<.001), D-dimer (SMD=1.92, p<.001), creatine kinase (SMD=1.68, p= 0.001) and interleukin-6 level (SMD=2.84, P=.001) in patients with fatal outcome. Funnel plots and Egger 's tests did not reveal any significant publication bias.
Conclusions: Features like older age, male gender, presence of co-morbidities and delayed hospitalization along with the laboratory findings consistent with infection, immune system activation, coagulation disorder and tissue damage could help clinicians to identify COVID-19 patients with poor prognosis at an early stage. J Microbiol Infect Dis 2019; 9(3):121-135.

Key words: COVID-19, risk factors, predictors, statistical association, outcome, adversity, death/ fatality, laboratory results


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Partha Sarathi Biswas
Articles by Devosri Sen
Articles by Anirban Homchoudhary
Articles by Deepika Makkar
Articles by Mahima Kapoor
Articles by Amandeep Goel
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Partha Sarathi Biswas, Devosri Sen, Anirban Homchoudhary, Deepika Makkar, Mahima Kapoor, Amandeep Goel. Association of demographic, clinical, laboratory, and radiological characteristics with outcomes of COVID-19 patients: A systematic review and Meta-analysis. J Microbiol Infect Dis. 2020; 10(3): 121-135 . doi:10.5799/jmid.790260

Web Style

Partha Sarathi Biswas, Devosri Sen, Anirban Homchoudhary, Deepika Makkar, Mahima Kapoor, Amandeep Goel. Association of demographic, clinical, laboratory, and radiological characteristics with outcomes of COVID-19 patients: A systematic review and Meta-analysis. https://www.jmidonline.org/?mno=302657124 [Access: November 22, 2024]. doi:10.5799/jmid.790260

AMA (American Medical Association) Style

Partha Sarathi Biswas, Devosri Sen, Anirban Homchoudhary, Deepika Makkar, Mahima Kapoor, Amandeep Goel. Association of demographic, clinical, laboratory, and radiological characteristics with outcomes of COVID-19 patients: A systematic review and Meta-analysis. J Microbiol Infect Dis. 2020; 10(3): 121-135 . doi:10.5799/jmid.790260


Vancouver/ICMJE Style

Partha Sarathi Biswas, Devosri Sen, Anirban Homchoudhary, Deepika Makkar, Mahima Kapoor, Amandeep Goel. Association of demographic, clinical, laboratory, and radiological characteristics with outcomes of COVID-19 patients: A systematic review and Meta-analysis. J Microbiol Infect Dis. (2020), [cited November 22, 2024]; 10(3): 121-135 . doi:10.5799/jmid.790260


Harvard Style

Partha Sarathi Biswas, Devosri Sen, Anirban Homchoudhary, Deepika Makkar, Mahima Kapoor, Amandeep Goel (2020) Association of demographic, clinical, laboratory, and radiological characteristics with outcomes of COVID-19 patients: A systematic review and Meta-analysis. J Microbiol Infect Dis, 10 (3), 121-135 . doi:10.5799/jmid.790260


Turabian Style

Partha Sarathi Biswas, Devosri Sen, Anirban Homchoudhary, Deepika Makkar, Mahima Kapoor, Amandeep Goel. 2020. Association of demographic, clinical, laboratory, and radiological characteristics with outcomes of COVID-19 patients: A systematic review and Meta-analysis. Journal of Microbiology and Infectious Diseases, 10 (3), 121-135 . doi:10.5799/jmid.790260


Chicago Style

Partha Sarathi Biswas, Devosri Sen, Anirban Homchoudhary, Deepika Makkar, Mahima Kapoor, Amandeep Goel. "Association of demographic, clinical, laboratory, and radiological characteristics with outcomes of COVID-19 patients: A systematic review and Meta-analysis." Journal of Microbiology and Infectious Diseases 10 (2020), 121-135 . doi:10.5799/jmid.790260


MLA (The Modern Language Association) Style

Partha Sarathi Biswas, Devosri Sen, Anirban Homchoudhary, Deepika Makkar, Mahima Kapoor, Amandeep Goel. "Association of demographic, clinical, laboratory, and radiological characteristics with outcomes of COVID-19 patients: A systematic review and Meta-analysis." Journal of Microbiology and Infectious Diseases 10.3 (2020), 121-135 . Print. doi:10.5799/jmid.790260


APA (American Psychological Association) Style

Partha Sarathi Biswas, Devosri Sen, Anirban Homchoudhary, Deepika Makkar, Mahima Kapoor, Amandeep Goel (2020) Association of demographic, clinical, laboratory, and radiological characteristics with outcomes of COVID-19 patients: A systematic review and Meta-analysis. Journal of Microbiology and Infectious Diseases, 10 (3), 121-135 . doi:10.5799/jmid.790260


Author LoginReviewer LoginAbout PublisherOpen Access PolicyEditorial PoliciesPeer Review PolicyPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About Journal of Microbiology and Infectious Diseases

Journal of Microbiology and Infectious Diseases (JMID) is an international "peer review" journal in microbiology, infectious diseases, virology, ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes

Editor-in-Chief

Journal of Microbiology and Infectious Diseases

Department of Microbiology and Parasitology 

Faculty of Veterinary Medicine

University of Tripoli

P.O. Box 13662, Tripoli, Libya