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2024, Vol: 14, Issue: 4
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Research Article 


Increasing penicillin resistance in pneumococci isolated from cerebrospinal fluid samples: Fifteen-year experience from a teaching hospital

Filiz Pehlivanoglu, Gonul Sengoz, Sevtap Gursoy.


Cited By:1

Abstract
Objective: There have been prominent changes in evaluation of resistance patterns of pneumococci and breakpoint values in recent years. We aimed to investigate the penicillin sensitivity of pneumococcal strains isolated from the ce¬rebrospinal fluid specimens between the years 1997-2011 in our hospital and determine the MIC values under the light of these changes.
Methods: Identification of pneumococci was made with conventional methods in patients with meningitis. MIC values for penicillin G were investigated by E test method in all strains. MIC values of pneumococci strains were evaluated ac¬cording to values determined by CLSI for meningitis isolates in 2008.
Results: A total of 57 strains were investigated in this study. The MIC range for penicillin was 0.016 - 0.75 μg/ml in S. pneumoniae strains. Seventy five percent of the strains were sensitive and eight strains (14%) had resistance. MIC50 value was sensitive, and a MIC90 value was resistant. The first resistant strain was detected in 2000, and three strains were resistant in the last year. When examined over the years increased resistance was 5.3% in the first five-year period seems to be 28.6% in the last five-year period.
Conclusions: Knowledge on penicillin resistance patterns and surveillance is very important in the empirical treatment in pneumococcal meningitis. J Microbiol Infect Dis 2014; 4(4): 136-140

Key words: S. pneumoniae, penicillin resistance, CSF, breakpoint.


 
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How to Cite this Article
Pubmed Style

Pehlivanoglu F, Sengoz G, Gursoy S. Increasing penicillin resistance in pneumococci isolated from cerebrospinal fluid samples: Fifteen-year experience from a teaching hospital. J Microbiol Infect Dis. 2014; 4(4): 136-140 . doi:10.5799/jmid2014.04.0156

Web Style

Pehlivanoglu F, Sengoz G, Gursoy S. Increasing penicillin resistance in pneumococci isolated from cerebrospinal fluid samples: Fifteen-year experience from a teaching hospital. https://www.jmidonline.org/?mno=302657035 [Access: January 09, 2025]. doi:10.5799/jmid2014.04.0156

AMA (American Medical Association) Style

Pehlivanoglu F, Sengoz G, Gursoy S. Increasing penicillin resistance in pneumococci isolated from cerebrospinal fluid samples: Fifteen-year experience from a teaching hospital. J Microbiol Infect Dis. 2014; 4(4): 136-140 . doi:10.5799/jmid2014.04.0156


Vancouver/ICMJE Style

Pehlivanoglu F, Sengoz G, Gursoy S. Increasing penicillin resistance in pneumococci isolated from cerebrospinal fluid samples: Fifteen-year experience from a teaching hospital. J Microbiol Infect Dis. (2014), [cited January 09, 2025]; 4(4): 136-140 . doi:10.5799/jmid2014.04.0156


Harvard Style

Pehlivanoglu, F., Sengoz, . G. & Gursoy, . S. (2014) Increasing penicillin resistance in pneumococci isolated from cerebrospinal fluid samples: Fifteen-year experience from a teaching hospital. J Microbiol Infect Dis, 4 (4), 136-140 . doi:10.5799/jmid2014.04.0156


Turabian Style

Pehlivanoglu, Filiz, Gonul Sengoz, and Sevtap Gursoy. 2014. Increasing penicillin resistance in pneumococci isolated from cerebrospinal fluid samples: Fifteen-year experience from a teaching hospital. Journal of Microbiology and Infectious Diseases, 4 (4), 136-140 . doi:10.5799/jmid2014.04.0156


Chicago Style

Pehlivanoglu, Filiz, Gonul Sengoz, and Sevtap Gursoy. "Increasing penicillin resistance in pneumococci isolated from cerebrospinal fluid samples: Fifteen-year experience from a teaching hospital." Journal of Microbiology and Infectious Diseases 4 (2014), 136-140 . doi:10.5799/jmid2014.04.0156


MLA (The Modern Language Association) Style

Pehlivanoglu, Filiz, Gonul Sengoz, and Sevtap Gursoy. "Increasing penicillin resistance in pneumococci isolated from cerebrospinal fluid samples: Fifteen-year experience from a teaching hospital." Journal of Microbiology and Infectious Diseases 4.4 (2014), 136-140 . Print. doi:10.5799/jmid2014.04.0156


APA (American Psychological Association) Style

Pehlivanoglu, F., Sengoz, . G. & Gursoy, . S. (2014) Increasing penicillin resistance in pneumococci isolated from cerebrospinal fluid samples: Fifteen-year experience from a teaching hospital. Journal of Microbiology and Infectious Diseases, 4 (4), 136-140 . doi:10.5799/jmid2014.04.0156


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