E-ISSN 2146-9369 | ISSN 2146-3158
 
2024, Vol: 14, Issue: 4
14 / 4Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles

Research Article 


Predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients

Ayse Batirel, Serap Gençer, Serdar Özer, Taflan Salepçi.


Cited By:1

Abstract
Objectives: To evaluate predictive values of serum amyloid A (SAA) and C-reactive protein (CRP) for infection and mor¬tality in patients with febrile neutropenia (FEN).
Methods: Daily measurement of serum SAA and CRP levels of patients during antibiotherapy for FEN.
Results: Sixty-five FEN episodes of 52 patients were evaluated. Median CRP and SAA levels on 1st day of FEN were 137 mg/L (23-420 mg/L) and 547 mg/L (11-1660 mg/L), respectively. For detection of infection of infection the sensitivity, positive predictive value (PPV), and negative predictive value (NPV) of SAA at a level of >80 mg/L were as 100%, 48% and 100%. Whilethe sensitivity, PPV, and NPV of CRP at a level of >50mg/L were as 86%, 47% and 60%, respectively. Predictive values of initial SAA and CRP levels for infection didn 't differ significantly (CRP: p=0.24, SAA: p=0.39). SAA and CRP levels on the last day of FEN course were significant for infection and mortality (for infection: p=0.003 for CRP and p=0.026 for SAA; for mortality: p<0.001 for CRP and p=0.021 for SAA). Both initial and daily SAA and CRP levels correlated with each other positively and statistically significantly (p<0.001). The area under the curve (AUC) on the re¬ceiver operating character (ROC) curve for CRP and SAA were 0.72 (p=0.003, 95% CI: 0.59-0.86) and 0.68 (p=0.19, 95% CI: 0.54-0.82), respectively.
Conclusions: Despite low predictive values in decision of initial therapy, these parameters would be helpful in decision of modification and evaluation of response to therapy. J Microbiol Infect Dis 2014; 4(4): 128-135

Key words: Fever, neutropenia, febrile neutropenia, C-reactive protein, serum amyloid A Ayşe Batırel, Serap Gencer, Serdar Özer, Taflan Salepci. Evaluation of predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients. J Microbiol Infect Dis 2014; 4(4): 128-135 doi: 10.5799/ahinjs.02.2014.04.0155


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Ayse Batirel
Articles by Serap Gençer
Articles by Serdar Özer
Articles by Taflan Salepçi
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Batirel A, Gencer S, Ozer S, Salepci T. Predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients. J Microbiol Infect Dis. 2014; 4(4): 128-135 . doi:10.5799/jmid2014.04.0155

Web Style

Batirel A, Gencer S, Ozer S, Salepci T. Predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients. https://www.jmidonline.org/?mno=302656980 [Access: January 09, 2025]. doi:10.5799/jmid2014.04.0155

AMA (American Medical Association) Style

Batirel A, Gencer S, Ozer S, Salepci T. Predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients. J Microbiol Infect Dis. 2014; 4(4): 128-135 . doi:10.5799/jmid2014.04.0155


Vancouver/ICMJE Style

Batirel A, Gencer S, Ozer S, Salepci T. Predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients. J Microbiol Infect Dis. (2014), [cited January 09, 2025]; 4(4): 128-135 . doi:10.5799/jmid2014.04.0155


Harvard Style

Batirel, A., Gencer, . S., Ozer, . S. & Salepci, . T. (2014) Predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients. J Microbiol Infect Dis, 4 (4), 128-135 . doi:10.5799/jmid2014.04.0155


Turabian Style

Batirel, Ayse, Serap Gencer, Serdar Ozer, and Taflan Salepci. 2014. Predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients. Journal of Microbiology and Infectious Diseases, 4 (4), 128-135 . doi:10.5799/jmid2014.04.0155


Chicago Style

Batirel, Ayse, Serap Gencer, Serdar Ozer, and Taflan Salepci. "Predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients." Journal of Microbiology and Infectious Diseases 4 (2014), 128-135 . doi:10.5799/jmid2014.04.0155


MLA (The Modern Language Association) Style

Batirel, Ayse, Serap Gencer, Serdar Ozer, and Taflan Salepci. "Predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients." Journal of Microbiology and Infectious Diseases 4.4 (2014), 128-135 . Print. doi:10.5799/jmid2014.04.0155


APA (American Psychological Association) Style

Batirel, A., Gencer, . S., Ozer, . S. & Salepci, . T. (2014) Predictive values of serum amyloid-A (SAA) and C-reactive protein (CRP) for infection in febrile neutropenic cancer patients. Journal of Microbiology and Infectious Diseases, 4 (4), 128-135 . doi:10.5799/jmid2014.04.0155


Author LoginReviewer LoginAbout PublisherOpen Access PolicyEditorial PoliciesPeer Review PolicyPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About Journal of Microbiology and Infectious Diseases

Journal of Microbiology and Infectious Diseases (JMID) is an international "peer review" journal in microbiology, infectious diseases, virology, ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes

Editor-in-Chief

Journal of Microbiology and Infectious Diseases

Department of Microbiology and Parasitology 

Faculty of Veterinary Medicine

University of Tripoli

P.O. Box 13662, Tripoli, Libya