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Title Page

Case Report 


Invasive orbital aspergillosis in an apparently immunocompetent host without evidence sinusitis

Jennifer Primeggia, George Cyriac, Princy Kumar.


Cited By:3

Abstract
Invasive aspergillosis is uncommon in healthy individuals. We report a case of Aspergillus fumigatus orbital cellulitis with intracranial extension in an apparently immunocompetent patient with a history of benign lymphoid hyperplasia of the lacrimal gland. A 68 year-old man with no signiicant past medical history underwent orbitotomy and biopsy of a lacrimal gland mass. Pathology showed benign lymphoid hyperplasia of the lacrimal gland and he completed radiation therapy. Three months after orbitotomy and one month after completion of radiation therapy, he presented with orbital cellulitis. Brain magnetic resonance imaging demonstrated invasion into the frontal lobe. Clinical and radiographic indings failed to improve with prolonged antibiotic therapy; transcranial orbitotomy with right frontal craniotomy for abscess drainage and orbit washout was performed. Intraoperative cultures grew Aspergillus fumigatus. The patient completed a six month course of therapy with oral voriconazole and has remained free from relapse with long-term follow-up. Eficacy of voriconazole was guided by serial imaging and voriconazole trough levels. Aspergillus may cause invasive disease in immunocompetent hosts, even without evidence of sinusitis, and should be considered in the dif-ferential diagnosis when patients do not demonstrate clinical improvement with antibiotic therapy. J Microbiol Infect Dis
2012; 2(3): 113-116


 
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How to Cite this Article
Pubmed Style

Primeggia J, Cyriac G, Kumar P. Invasive orbital aspergillosis in an apparently immunocompetent host without evidence sinusitis. J Microbiol Infect Dis. 2012; 2(3): 113-116 .

doi:10.5799/jmid2012.03.0054

Web Style

Primeggia J, Cyriac G, Kumar P. Invasive orbital aspergillosis in an apparently immunocompetent host without evidence sinusitis. https://www.jmidonline.org/?mno=302657292 [Access: June 27, 2026].

doi:10.5799/jmid2012.03.0054

AMA (American Medical Association) Style

Primeggia J, Cyriac G, Kumar P. Invasive orbital aspergillosis in an apparently immunocompetent host without evidence sinusitis. J Microbiol Infect Dis. 2012; 2(3): 113-116 .


doi:10.5799/jmid2012.03.0054

Vancouver/ICMJE Style

Primeggia J, Cyriac G, Kumar P. Invasive orbital aspergillosis in an apparently immunocompetent host without evidence sinusitis. J Microbiol Infect Dis. (2012), [cited June 27, 2026]; 2(3): 113-116 .


doi:10.5799/jmid2012.03.0054

Harvard Style

Primeggia, J., Cyriac, . G. & Kumar, . P. (2012) Invasive orbital aspergillosis in an apparently immunocompetent host without evidence sinusitis. J Microbiol Infect Dis, 2 (3), 113-116 .


doi:10.5799/jmid2012.03.0054

Turabian Style

Primeggia, Jennifer, George Cyriac, and Princy Kumar. 2012. Invasive orbital aspergillosis in an apparently immunocompetent host without evidence sinusitis. Journal of Microbiology and Infectious Diseases, 2 (3), 113-116 .


doi:10.5799/jmid2012.03.0054

Chicago Style

Primeggia, Jennifer, George Cyriac, and Princy Kumar. "Invasive orbital aspergillosis in an apparently immunocompetent host without evidence sinusitis." Journal of Microbiology and Infectious Diseases 2 (2012), 113-116 .


doi:10.5799/jmid2012.03.0054

MLA (The Modern Language Association) Style

Primeggia, Jennifer, George Cyriac, and Princy Kumar. "Invasive orbital aspergillosis in an apparently immunocompetent host without evidence sinusitis." Journal of Microbiology and Infectious Diseases 2.3 (2012), 113-116 . Print.


doi:10.5799/jmid2012.03.0054

APA (American Psychological Association) Style

Primeggia, J., Cyriac, . G. & Kumar, . P. (2012) Invasive orbital aspergillosis in an apparently immunocompetent host without evidence sinusitis. Journal of Microbiology and Infectious Diseases, 2 (3), 113-116 .


doi:10.5799/jmid2012.03.0054

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