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2024, Vol: 14, Issue: 4
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Case Report 


Cryptococcal cellulitis in a diabetic with nephropathy on adalimumab therapy for rheumatoid arthritis

Christine Ann Moore, Imranali Khan, Almira Opardija, Parasbhai Patel.


Abstract
Cutaneous infection with Cryptococcus neoformans is rare but can occur in the setting of rheumatoid arthritis due to immunosuppression. Risk factors include chronic kidney disease and use of tumor necrosis factor-alpha (TNF-α) inhibitor adalimumab. We report the fourth case of primary cutaneous cryptococcosis (PCC) in a diabetic female more than 60 years old living in rural Northwest Tennessee and taking adalimumab for rheumatoid arthritis. In a literature review of existing cases, this is the second case involving simultaneous chronic kidney disease and the first case in a diabetic and following extended TNF-α inhibitor immunosuppression monotherapy. Physicians should consider cryptococcal infection in a patient who develops cellulitis that is unresponsive to empiric therapy. In addition, it is imperative to monitor rheumatoid arthritis patients taking adalimumab closely and consider alternative agents in those with pre-existing immunosuppression or known risk factors for opportunistic infections as primary prevention. J Microbiol Infect Dis 2017; 7(3):161-164

Key words: Cryptococcus neoformans, rheumatoid arthritis, adalimumab, diabetes mellitus, chronic kidney disease


 
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How to Cite this Article
Pubmed Style

Moore CA, Khan I, Opardija A, Patel P. Cryptococcal cellulitis in a diabetic with nephropathy on adalimumab therapy for rheumatoid arthritis. J Microbiol Infect Dis. 2017; 7(3): 160-163 . doi:10.5799/jmid.367623

Web Style

Moore CA, Khan I, Opardija A, Patel P. Cryptococcal cellulitis in a diabetic with nephropathy on adalimumab therapy for rheumatoid arthritis. https://www.jmidonline.org/?mno=302657249 [Access: January 09, 2025]. doi:10.5799/jmid.367623

AMA (American Medical Association) Style

Moore CA, Khan I, Opardija A, Patel P. Cryptococcal cellulitis in a diabetic with nephropathy on adalimumab therapy for rheumatoid arthritis. J Microbiol Infect Dis. 2017; 7(3): 160-163 . doi:10.5799/jmid.367623


Vancouver/ICMJE Style

Moore CA, Khan I, Opardija A, Patel P. Cryptococcal cellulitis in a diabetic with nephropathy on adalimumab therapy for rheumatoid arthritis. J Microbiol Infect Dis. (2017), [cited January 09, 2025]; 7(3): 160-163 . doi:10.5799/jmid.367623


Harvard Style

Moore, C. A., Khan, . I., Opardija, . A. & Patel, . P. (2017) Cryptococcal cellulitis in a diabetic with nephropathy on adalimumab therapy for rheumatoid arthritis. J Microbiol Infect Dis, 7 (3), 160-163 . doi:10.5799/jmid.367623


Turabian Style

Moore, Christine Ann, Imranali Khan, Almira Opardija, and Parasbhai Patel. 2017. Cryptococcal cellulitis in a diabetic with nephropathy on adalimumab therapy for rheumatoid arthritis. Journal of Microbiology and Infectious Diseases, 7 (3), 160-163 . doi:10.5799/jmid.367623


Chicago Style

Moore, Christine Ann, Imranali Khan, Almira Opardija, and Parasbhai Patel. "Cryptococcal cellulitis in a diabetic with nephropathy on adalimumab therapy for rheumatoid arthritis." Journal of Microbiology and Infectious Diseases 7 (2017), 160-163 . doi:10.5799/jmid.367623


MLA (The Modern Language Association) Style

Moore, Christine Ann, Imranali Khan, Almira Opardija, and Parasbhai Patel. "Cryptococcal cellulitis in a diabetic with nephropathy on adalimumab therapy for rheumatoid arthritis." Journal of Microbiology and Infectious Diseases 7.3 (2017), 160-163 . Print. doi:10.5799/jmid.367623


APA (American Psychological Association) Style

Moore, C. A., Khan, . I., Opardija, . A. & Patel, . P. (2017) Cryptococcal cellulitis in a diabetic with nephropathy on adalimumab therapy for rheumatoid arthritis. Journal of Microbiology and Infectious Diseases, 7 (3), 160-163 . doi:10.5799/jmid.367623


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Journal of Microbiology and Infectious Diseases (JMID) is an international "peer review" journal in microbiology, infectious diseases, virology, ... Read more.



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Journal of Microbiology and Infectious Diseases

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