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Research Article 


Nuclear Matrix Protein 22 and Cytological Findings in Urine of Residents of Urogenital Schistosomiasis in an Endemic Community

Ukeme Gideon Etuk, Paul Columba Inyang-etoh, Mfoniso Iniobong Udonkang, Emmanuel Monday Japhet, Uloma Opara-osuoha.


Cited By:1

Abstract
Objective: Urogenital schistosomiasis has continued to cause severe morbidity among residents of Adim community. The aim of the study was to screen both adults and children residents of this community for urine tumour markers and to stain cytologically for epithelial changes which indicate the risk of them being predispose to bladder cancer.
Methods: Terminal urine samples were collected by simple random sampling method from 350 subjects (300 children and 50 adults) in Adim Community for microscopy using standard parasitological methods, urinalysis, ELISA-based Nuclear Matrix Protein 22 (NMP22), and Papanicolaou- and Alcian blue-stained cytological analysis.
Results: S. haematobium infection was observed in 18 (5.1%), proteinuria 21 (6.0%) and hematuria 30 (8.6%). Age group 25-31 years had the highest level of NMP22 values (1692.3 ± 46.4) among the adults and children. The difference was statistically significant (P=0.001). In general male subjects had higher NMP22 values (1214.6+ 487.1) than females (1198.9+ 472.9) (P=0.389). The cytological findings showed abnormal epithelial cells in Papanicolaou stain 2 (0.57%) and hyaluronic acid 1 (0.29%). Cytological findings with Papanicolaou stain revealed metaplasia 1 (0.3%), mild dysplasia 1 (0.3%), inflammation 6 (1.7%), and hyaluronic acid positive cells 1 (0.29%).
Conclusion: The study showed S. haematobium prevalence of 5.1% but NMP 22 values were not positive for bladder cancer. The cytological findings revealed metaplasia, mild dysplasia and hyaluronic acid positive epithelial changes which are indicators for bladder cancer. J Microbiol Infect Dis 2018; 8(3):89-96

Key words: Bladder cancer, Cytology, Nuclear Matrix Protein 22, Urogenital Schistosomiasis


 
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How to Cite this Article
Pubmed Style

Etuk UG, Inyang-etoh PC, Udonkang MI, Japhet EM, Opara-osuoha U. Nuclear Matrix Protein 22 and Cytological Findings in Urine of Residents of Urogenital Schistosomiasis in an Endemic Community. J Microbiol Infect Dis. 2018; 8(3): 89-96 . doi:10.5799/jmid.458454

Web Style

Etuk UG, Inyang-etoh PC, Udonkang MI, Japhet EM, Opara-osuoha U. Nuclear Matrix Protein 22 and Cytological Findings in Urine of Residents of Urogenital Schistosomiasis in an Endemic Community. https://www.jmidonline.org/?mno=302657180 [Access: January 09, 2025]. doi:10.5799/jmid.458454

AMA (American Medical Association) Style

Etuk UG, Inyang-etoh PC, Udonkang MI, Japhet EM, Opara-osuoha U. Nuclear Matrix Protein 22 and Cytological Findings in Urine of Residents of Urogenital Schistosomiasis in an Endemic Community. J Microbiol Infect Dis. 2018; 8(3): 89-96 . doi:10.5799/jmid.458454


Vancouver/ICMJE Style

Etuk UG, Inyang-etoh PC, Udonkang MI, Japhet EM, Opara-osuoha U. Nuclear Matrix Protein 22 and Cytological Findings in Urine of Residents of Urogenital Schistosomiasis in an Endemic Community. J Microbiol Infect Dis. (2018), [cited January 09, 2025]; 8(3): 89-96 . doi:10.5799/jmid.458454


Harvard Style

Etuk, U. G., Inyang-etoh, . P. C., Udonkang, . M. I., Japhet, . E. M. & Opara-osuoha, . U. (2018) Nuclear Matrix Protein 22 and Cytological Findings in Urine of Residents of Urogenital Schistosomiasis in an Endemic Community. J Microbiol Infect Dis, 8 (3), 89-96 . doi:10.5799/jmid.458454


Turabian Style

Etuk, Ukeme Gideon, Paul Columba Inyang-etoh, Mfoniso Iniobong Udonkang, Emmanuel Monday Japhet, and Uloma Opara-osuoha. 2018. Nuclear Matrix Protein 22 and Cytological Findings in Urine of Residents of Urogenital Schistosomiasis in an Endemic Community. Journal of Microbiology and Infectious Diseases, 8 (3), 89-96 . doi:10.5799/jmid.458454


Chicago Style

Etuk, Ukeme Gideon, Paul Columba Inyang-etoh, Mfoniso Iniobong Udonkang, Emmanuel Monday Japhet, and Uloma Opara-osuoha. "Nuclear Matrix Protein 22 and Cytological Findings in Urine of Residents of Urogenital Schistosomiasis in an Endemic Community." Journal of Microbiology and Infectious Diseases 8 (2018), 89-96 . doi:10.5799/jmid.458454


MLA (The Modern Language Association) Style

Etuk, Ukeme Gideon, Paul Columba Inyang-etoh, Mfoniso Iniobong Udonkang, Emmanuel Monday Japhet, and Uloma Opara-osuoha. "Nuclear Matrix Protein 22 and Cytological Findings in Urine of Residents of Urogenital Schistosomiasis in an Endemic Community." Journal of Microbiology and Infectious Diseases 8.3 (2018), 89-96 . Print. doi:10.5799/jmid.458454


APA (American Psychological Association) Style

Etuk, U. G., Inyang-etoh, . P. C., Udonkang, . M. I., Japhet, . E. M. & Opara-osuoha, . U. (2018) Nuclear Matrix Protein 22 and Cytological Findings in Urine of Residents of Urogenital Schistosomiasis in an Endemic Community. Journal of Microbiology and Infectious Diseases, 8 (3), 89-96 . doi:10.5799/jmid.458454


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