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Research Article 


Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey

Sukran Kose, Gursel Ersan, Suheyla Serin Senger, Gulsun Akincioglu, Melda Ulusoy, Gulgun Akkoclu.


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Abstract
Objectives: The goal of therapy in chronic hepatitis B infection (CHB) is to impede liver injury by suppressing viral replication. The study was aimed to determine the eficacy of tenofovir (TDF) in CHB infection for 48 weeks.
Materials and methods: We retrospectively analyzed the data of 45 CHB patients treated by tenofovir. The patients were divided into two groups based on their hepatitis B e antigen status (HBeAg). Those who were eligible to therapy received TDF 300 mg once daily for 48 weeks. Serum alanine aminotransferase levels (ALT), hepatitis B virus DNA (HBV DNA), and viral serological markers were checked at three-month intervals. Liver biopsy scores were determined in all patients.
Results: The mean age ± standard deviation (SD) was 35.8 ± 17.0 years, 26 (57.8 %) were male, and seven patients (15.5%) were treatment-experienced by a nucleos(t)ide analogue before TDF. HBeAg was positive in 17 (37.8%) patients. At week 48 among HBeAg positive (HBeAg +) patients ' biochemical and virological response rates at month-3, -6 and -12 were 64.7%, and 100%, 70.6%, and 94.1%, and 88.2%, and 64.7%, respectively. The serological response in HBeAg + patients was 29.4%. For HBeAg negative (HBeAg -) patients; biochemical, and virological response rates were 64.3%, and 96.4% at month 3; 82.1%, and 96.4% at month 6; and 100%, and 85.7% at month 12, respectively. At week 48 both groups had signiicant virological response (p<0.001).
Conclusion: Treatment in CHB with TDF leads to HBV DNA suppression without evident resistance for 48-week, and is well tolerated. J Microbiol Infect Dis 2012; 2(3): 87-92


 
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How to Cite this Article
Pubmed Style

Sukran Kose, Gursel Ersan, Suheyla Serin Senger, Gulsun Akincioglu, Melda Ulusoy, Gulgun Akkoclu. Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey. J Microbiol Infect Dis. 2012; 2(3): 87-92 . doi:10.5799/jmid2012.03.0050

Web Style

Sukran Kose, Gursel Ersan, Suheyla Serin Senger, Gulsun Akincioglu, Melda Ulusoy, Gulgun Akkoclu. Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey. https://www.jmidonline.org/?mno=302657167 [Access: November 24, 2024]. doi:10.5799/jmid2012.03.0050

AMA (American Medical Association) Style

Sukran Kose, Gursel Ersan, Suheyla Serin Senger, Gulsun Akincioglu, Melda Ulusoy, Gulgun Akkoclu. Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey. J Microbiol Infect Dis. 2012; 2(3): 87-92 . doi:10.5799/jmid2012.03.0050


Vancouver/ICMJE Style

Sukran Kose, Gursel Ersan, Suheyla Serin Senger, Gulsun Akincioglu, Melda Ulusoy, Gulgun Akkoclu. Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey. J Microbiol Infect Dis. (2012), [cited November 24, 2024]; 2(3): 87-92 . doi:10.5799/jmid2012.03.0050


Harvard Style

Sukran Kose, Gursel Ersan, Suheyla Serin Senger, Gulsun Akincioglu, Melda Ulusoy, Gulgun Akkoclu (2012) Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey. J Microbiol Infect Dis, 2 (3), 87-92 . doi:10.5799/jmid2012.03.0050


Turabian Style

Sukran Kose, Gursel Ersan, Suheyla Serin Senger, Gulsun Akincioglu, Melda Ulusoy, Gulgun Akkoclu. 2012. Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey. Journal of Microbiology and Infectious Diseases, 2 (3), 87-92 . doi:10.5799/jmid2012.03.0050


Chicago Style

Sukran Kose, Gursel Ersan, Suheyla Serin Senger, Gulsun Akincioglu, Melda Ulusoy, Gulgun Akkoclu. "Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey." Journal of Microbiology and Infectious Diseases 2 (2012), 87-92 . doi:10.5799/jmid2012.03.0050


MLA (The Modern Language Association) Style

Sukran Kose, Gursel Ersan, Suheyla Serin Senger, Gulsun Akincioglu, Melda Ulusoy, Gulgun Akkoclu. "Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey." Journal of Microbiology and Infectious Diseases 2.3 (2012), 87-92 . Print. doi:10.5799/jmid2012.03.0050


APA (American Psychological Association) Style

Sukran Kose, Gursel Ersan, Suheyla Serin Senger, Gulsun Akincioglu, Melda Ulusoy, Gulgun Akkoclu (2012) Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey. Journal of Microbiology and Infectious Diseases, 2 (3), 87-92 . doi:10.5799/jmid2012.03.0050


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Prof. Ibrahim Eldaghayes

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Journal of Microbiology and Infectious Diseases

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