E-ISSN 2146-9369 | ISSN 2146-3158
 
2024, Vol: 14, Issue: 3
14 / 3Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles

Research Article 


Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever

Sami Kınıklı, Neziha Yılmaz, Salih Cesur, Ahmet Aydemir, Hasan Irmak, Cemal Bulut, Ali Pekcan Demiröz, Gülay Kınıklı.


Abstract
Objectives: Crimean-Congo hemorrhagic fever (CCHF) is a tick borne zoonotic infection. Up till now knowledge about pathogenesis of the disease is limited. Cytokine response is quite important during this infection. The aim of this study was to determine the serum tumor necrosis factor-alpha (TNF-α) and the interleukin-4 (IL-4) levels in patients with CCHF and compare with those of healthy controls.
Materials and methods: Forty-two adult CCHF patients and 40 healthy subjects were included in this study. The diagnosis of CCHF was based upon anti-CCHF virus IgM positivity (ELISA method), and/or positivity in real time-polymerase chain reaction (RT-PCR) in acute phase serum samples. Serum TNF-α and IL-4 levels were determined by ELISA method.
Results: In patients with CCHF the mean serum TNF-α level was significantly higher than the control group (15.01 vs. 7.69 pg/ml; p<0.05) and also the mean serum IL-4 levels were significantly higher than the control group (1.07 vs. 0 pg/ml; p<0.05).
Conclusion: The levels of serum TNF-α and IL-4 in CCHF patients were found higher than healthy controls. These cytokines might play an important role in the pathogenesis of CCHF. J Microbiol Infect Dis 2011;1 (3):134-137

Key words: Crimean-Congo Hemorrhagic Fever, IL-4, TNF-α


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Sami Kınıklı
Articles by Neziha Yılmaz
Articles by Salih Cesur
Articles by Ahmet Aydemir
Articles by Hasan Irmak
Articles by Cemal Bulut
Articles by Ali Pekcan Demiröz
Articles by Gülay Kınıklı
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Sami Kınıklı, Neziha Yılmaz, Salih Cesur, Ahmet Aydemir, Hasan Irmak, Cemal Bulut, Ali Pekcan Demiroz, Gulay Kınıklı. Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever. J Microbiol Infect Dis. 2011; 1(3): 134-137 . doi:10.5799/jmid2011.03.0030

Web Style

Sami Kınıklı, Neziha Yılmaz, Salih Cesur, Ahmet Aydemir, Hasan Irmak, Cemal Bulut, Ali Pekcan Demiroz, Gulay Kınıklı. Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever. https://www.jmidonline.org/?mno=302657146 [Access: November 22, 2024]. doi:10.5799/jmid2011.03.0030

AMA (American Medical Association) Style

Sami Kınıklı, Neziha Yılmaz, Salih Cesur, Ahmet Aydemir, Hasan Irmak, Cemal Bulut, Ali Pekcan Demiroz, Gulay Kınıklı. Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever. J Microbiol Infect Dis. 2011; 1(3): 134-137 . doi:10.5799/jmid2011.03.0030


Vancouver/ICMJE Style

Sami Kınıklı, Neziha Yılmaz, Salih Cesur, Ahmet Aydemir, Hasan Irmak, Cemal Bulut, Ali Pekcan Demiroz, Gulay Kınıklı. Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever. J Microbiol Infect Dis. (2011), [cited November 22, 2024]; 1(3): 134-137 . doi:10.5799/jmid2011.03.0030


Harvard Style

Sami Kınıklı, Neziha Yılmaz, Salih Cesur, Ahmet Aydemir, Hasan Irmak, Cemal Bulut, Ali Pekcan Demiroz, Gulay Kınıklı (2011) Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever. J Microbiol Infect Dis, 1 (3), 134-137 . doi:10.5799/jmid2011.03.0030


Turabian Style

Sami Kınıklı, Neziha Yılmaz, Salih Cesur, Ahmet Aydemir, Hasan Irmak, Cemal Bulut, Ali Pekcan Demiroz, Gulay Kınıklı. 2011. Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever. Journal of Microbiology and Infectious Diseases, 1 (3), 134-137 . doi:10.5799/jmid2011.03.0030


Chicago Style

Sami Kınıklı, Neziha Yılmaz, Salih Cesur, Ahmet Aydemir, Hasan Irmak, Cemal Bulut, Ali Pekcan Demiroz, Gulay Kınıklı. "Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever." Journal of Microbiology and Infectious Diseases 1 (2011), 134-137 . doi:10.5799/jmid2011.03.0030


MLA (The Modern Language Association) Style

Sami Kınıklı, Neziha Yılmaz, Salih Cesur, Ahmet Aydemir, Hasan Irmak, Cemal Bulut, Ali Pekcan Demiroz, Gulay Kınıklı. "Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever." Journal of Microbiology and Infectious Diseases 1.3 (2011), 134-137 . Print. doi:10.5799/jmid2011.03.0030


APA (American Psychological Association) Style

Sami Kınıklı, Neziha Yılmaz, Salih Cesur, Ahmet Aydemir, Hasan Irmak, Cemal Bulut, Ali Pekcan Demiroz, Gulay Kınıklı (2011) Serum tumor necrosis factor alpha and interleukin-4 levels in patients with Crimean-Congo Hemorrhagic Fever. Journal of Microbiology and Infectious Diseases, 1 (3), 134-137 . doi:10.5799/jmid2011.03.0030


Author LoginReviewer LoginAbout PublisherOpen Access PolicyEditorial PoliciesPeer Review PolicyPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About Journal of Microbiology and Infectious Diseases

Journal of Microbiology and Infectious Diseases (JMID) is an international "peer review" journal in microbiology, infectious diseases, virology, ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes

Editor-in-Chief

Journal of Microbiology and Infectious Diseases

Department of Microbiology and Parasitology 

Faculty of Veterinary Medicine

University of Tripoli

P.O. Box 13662, Tripoli, Libya