E-ISSN 2146-9369 | ISSN 2146-3158
 
2024, Vol: 14, Issue: 3
14 / 3Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles

Research Article 


Prognostic value of cytokines (TNF-α, IL-10, Leptin) and C-reactive protein serum levels in adult patients with nosocomial sepsis

Salih Cesur, Ali Şengül, Yasemin Kurtoğlu, Yasin Kalpakçı, Selcan Arslan Özel, Aybars Bilgetürk, Hakan Erdem, Turan Aslan, Sami Kınıklı, Can Polat Eyigün, Zeynep Bıyıklı.


Abstract
Objectives: The purpose of this trial was to investigate in patients with sepsis, the correlation between prognosis of disease and factors, which influence prognosis like gender, focus of infection, bacterial growth in blood culture, growing pathogens in addition to serum levels of cytokines (TNF-α, IL-10, leptin) and C-reactive protein.
Material and methods: Forty-six adult patients with sepsis and 55 healthy adults as control group were enrolled in this study. Serum cytokine (TNF-α, IL-10 and leptin) levels were determined by ELISA method and C-reactive protein (CRP) levels were measured by nephelometric method. Serum cytokine and CRP levels on day 0 (initial), day 3 and day 5 were compared in surviving sepsis patients and patients who died because of sepsis.
Results: Serum IL-10 level on day 0 (initial) of adult patients who died as a result of sepsis was found to be higher than surviving patients and the difference was statistically significant (p=0.025). On 3rd day of treatment, serum TNF-α and CRP levels of patients who dies because of sepsis were higher than values of surviving patients (for TNF-α p=0.033, for CRP p=0.026). In adult patient group with sepsis who died on the 5th day of treatment, serum TNF-α level was significantly higher than levels in surviving patients (p=0.030).
Conclusion: It was determined that in patients who died due to sepsis, initial serum IL-10 level, TNF- α and CRP levels on 3rd day of treatment and finally on 5th day of treatment, only serum TNF- α level was higher than surviving patients. We believe that determining serum TNF-α and IL-10 levels in patients with sepsis before and during treatment will help clinicians to clarify prognosis and enable them to implement appropriate treatment modifications. J Microbiol Infect Dis 2011;1 (3):101-109

Key words: Sepsis, cytokines, CRP, prognosis


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Salih Cesur
Articles by Ali Şengül
Articles by Yasemin Kurtoğlu
Articles by Yasin Kalpakçı
Articles by Selcan Arslan Özel
Articles by Aybars Bilgetürk
Articles by Hakan Erdem
Articles by Turan Aslan
Articles by Sami Kınıklı
Articles by Can Polat Eyigün
Articles by Zeynep Bıyıklı
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Salih Cesur, Ali Şengul, Yasemin Kurtoğlu, Yasin Kalpakcı, Selcan Arslan Ozel, Aybars Bilgeturk, Hakan Erdem, Turan Aslan, Sami Kınıklı, Can Polat Eyigun, Zeynep Bıyıklı. Prognostic value of cytokines (TNF-α, IL-10, Leptin) and C-reactive protein serum levels in adult patients with nosocomial sepsis. J Microbiol Infect Dis. 2011; 1(3): 101-109 . doi:10.5799/jmid2011.03.0024

Web Style

Salih Cesur, Ali Şengul, Yasemin Kurtoğlu, Yasin Kalpakcı, Selcan Arslan Ozel, Aybars Bilgeturk, Hakan Erdem, Turan Aslan, Sami Kınıklı, Can Polat Eyigun, Zeynep Bıyıklı. Prognostic value of cytokines (TNF-α, IL-10, Leptin) and C-reactive protein serum levels in adult patients with nosocomial sepsis. https://www.jmidonline.org/?mno=302657145 [Access: November 22, 2024]. doi:10.5799/jmid2011.03.0024

AMA (American Medical Association) Style

Salih Cesur, Ali Şengul, Yasemin Kurtoğlu, Yasin Kalpakcı, Selcan Arslan Ozel, Aybars Bilgeturk, Hakan Erdem, Turan Aslan, Sami Kınıklı, Can Polat Eyigun, Zeynep Bıyıklı. Prognostic value of cytokines (TNF-α, IL-10, Leptin) and C-reactive protein serum levels in adult patients with nosocomial sepsis. J Microbiol Infect Dis. 2011; 1(3): 101-109 . doi:10.5799/jmid2011.03.0024


Vancouver/ICMJE Style

Salih Cesur, Ali Şengul, Yasemin Kurtoğlu, Yasin Kalpakcı, Selcan Arslan Ozel, Aybars Bilgeturk, Hakan Erdem, Turan Aslan, Sami Kınıklı, Can Polat Eyigun, Zeynep Bıyıklı. Prognostic value of cytokines (TNF-α, IL-10, Leptin) and C-reactive protein serum levels in adult patients with nosocomial sepsis. J Microbiol Infect Dis. (2011), [cited November 22, 2024]; 1(3): 101-109 . doi:10.5799/jmid2011.03.0024


Harvard Style

Salih Cesur, Ali Şengul, Yasemin Kurtoğlu, Yasin Kalpakcı, Selcan Arslan Ozel, Aybars Bilgeturk, Hakan Erdem, Turan Aslan, Sami Kınıklı, Can Polat Eyigun, Zeynep Bıyıklı (2011) Prognostic value of cytokines (TNF-α, IL-10, Leptin) and C-reactive protein serum levels in adult patients with nosocomial sepsis. J Microbiol Infect Dis, 1 (3), 101-109 . doi:10.5799/jmid2011.03.0024


Turabian Style

Salih Cesur, Ali Şengul, Yasemin Kurtoğlu, Yasin Kalpakcı, Selcan Arslan Ozel, Aybars Bilgeturk, Hakan Erdem, Turan Aslan, Sami Kınıklı, Can Polat Eyigun, Zeynep Bıyıklı. 2011. Prognostic value of cytokines (TNF-α, IL-10, Leptin) and C-reactive protein serum levels in adult patients with nosocomial sepsis. Journal of Microbiology and Infectious Diseases, 1 (3), 101-109 . doi:10.5799/jmid2011.03.0024


Chicago Style

Salih Cesur, Ali Şengul, Yasemin Kurtoğlu, Yasin Kalpakcı, Selcan Arslan Ozel, Aybars Bilgeturk, Hakan Erdem, Turan Aslan, Sami Kınıklı, Can Polat Eyigun, Zeynep Bıyıklı. "Prognostic value of cytokines (TNF-α, IL-10, Leptin) and C-reactive protein serum levels in adult patients with nosocomial sepsis." Journal of Microbiology and Infectious Diseases 1 (2011), 101-109 . doi:10.5799/jmid2011.03.0024


MLA (The Modern Language Association) Style

Salih Cesur, Ali Şengul, Yasemin Kurtoğlu, Yasin Kalpakcı, Selcan Arslan Ozel, Aybars Bilgeturk, Hakan Erdem, Turan Aslan, Sami Kınıklı, Can Polat Eyigun, Zeynep Bıyıklı. "Prognostic value of cytokines (TNF-α, IL-10, Leptin) and C-reactive protein serum levels in adult patients with nosocomial sepsis." Journal of Microbiology and Infectious Diseases 1.3 (2011), 101-109 . Print. doi:10.5799/jmid2011.03.0024


APA (American Psychological Association) Style

Salih Cesur, Ali Şengul, Yasemin Kurtoğlu, Yasin Kalpakcı, Selcan Arslan Ozel, Aybars Bilgeturk, Hakan Erdem, Turan Aslan, Sami Kınıklı, Can Polat Eyigun, Zeynep Bıyıklı (2011) Prognostic value of cytokines (TNF-α, IL-10, Leptin) and C-reactive protein serum levels in adult patients with nosocomial sepsis. Journal of Microbiology and Infectious Diseases, 1 (3), 101-109 . doi:10.5799/jmid2011.03.0024


Author LoginReviewer LoginAbout PublisherOpen Access PolicyEditorial PoliciesPeer Review PolicyPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About Journal of Microbiology and Infectious Diseases

Journal of Microbiology and Infectious Diseases (JMID) is an international "peer review" journal in microbiology, infectious diseases, virology, ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes

Editor-in-Chief

Journal of Microbiology and Infectious Diseases

Department of Microbiology and Parasitology 

Faculty of Veterinary Medicine

University of Tripoli

P.O. Box 13662, Tripoli, Libya