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Research Article 


In-vitro activity of oxymino-cephalosporins with and without sulbactam against Class A Extended-spectrum β-lactamase producing E.coli

Fetiye Kolaylı, Cansu Semiz, Haluk Vahaboğlu.


Cited By:2

Abstract
Objectives: The primary aim of this study was to determine the activities of ceftazidime and cefepime combined to sulbactam against class A extended-spectrum β lactamases (ESBLs).
Materials and methods: Eight university hospitals participated to the study by submitting isolates those were recovered during a six-month period in 2010 from various clinical materials. Sulbactam was tested in two fixed concentrations of 4 mg/l and 8 mg/l. Isolates showing a fourfold or more decrease in the MIC of an oxyimino-cephalosporin with sulbactam were defined as ESBL producers. Isolates were screened for CTX-M group 1 extended-spectrum β lactamases by PCR.
Results: A total of 149 ESBL-positive E.coli were studied. Isolates were uniformly susceptible to carbapenems and highly resistant to ciprofloxacin. According to CLSI breakpoints, 28% (42/149) of isolates were susceptible to ceftazidime and 32% (47/149) to cefepime. With 4 mg/L and 8 mg/L sulbactam supplement, ceftazidime susceptibility rose to 69% (103/149) and 88% (131/149), while cefepime susceptibility rose to 86 % (128/149) and 95% (141/149), respectively. PCR screening revealed that 63% (94/149) of the isolates were positive for blaCTX-M and 38% (36/94) of these were on the O25b-ST131 clone.
Conclusion: Ceftazidime plus sulbactam and cefepime plus sulbactam showed remarkable activity against ESBL-positive E.coli. J Microbiol Infect Dis 2011;1(3):87-92

Key words: Extended-spectrum β-lactamase, Escherichia coli,ceftazidime, cefepim


 
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Pubmed Style

Fetiye Kolaylı, Cansu Semiz, Haluk Vahaboğlu. In-vitro activity of oxymino-cephalosporins with and without sulbactam against Class A Extended-spectrum β-lactamase producing E.coli. J Microbiol Infect Dis. 2011; 1(3): 87-92. doi:10.5799/jmid2011.03.0022

Web Style

Fetiye Kolaylı, Cansu Semiz, Haluk Vahaboğlu. In-vitro activity of oxymino-cephalosporins with and without sulbactam against Class A Extended-spectrum β-lactamase producing E.coli. https://www.jmidonline.org/?mno=302657033 [Access: November 23, 2024]. doi:10.5799/jmid2011.03.0022

AMA (American Medical Association) Style

Fetiye Kolaylı, Cansu Semiz, Haluk Vahaboğlu. In-vitro activity of oxymino-cephalosporins with and without sulbactam against Class A Extended-spectrum β-lactamase producing E.coli. J Microbiol Infect Dis. 2011; 1(3): 87-92. doi:10.5799/jmid2011.03.0022


Vancouver/ICMJE Style

Fetiye Kolaylı, Cansu Semiz, Haluk Vahaboğlu. In-vitro activity of oxymino-cephalosporins with and without sulbactam against Class A Extended-spectrum β-lactamase producing E.coli. J Microbiol Infect Dis. (2011), [cited November 23, 2024]; 1(3): 87-92. doi:10.5799/jmid2011.03.0022


Harvard Style

Fetiye Kolaylı, Cansu Semiz, Haluk Vahaboğlu (2011) In-vitro activity of oxymino-cephalosporins with and without sulbactam against Class A Extended-spectrum β-lactamase producing E.coli. J Microbiol Infect Dis, 1 (3), 87-92. doi:10.5799/jmid2011.03.0022


Turabian Style

Fetiye Kolaylı, Cansu Semiz, Haluk Vahaboğlu. 2011. In-vitro activity of oxymino-cephalosporins with and without sulbactam against Class A Extended-spectrum β-lactamase producing E.coli. Journal of Microbiology and Infectious Diseases, 1 (3), 87-92. doi:10.5799/jmid2011.03.0022


Chicago Style

Fetiye Kolaylı, Cansu Semiz, Haluk Vahaboğlu. "In-vitro activity of oxymino-cephalosporins with and without sulbactam against Class A Extended-spectrum β-lactamase producing E.coli." Journal of Microbiology and Infectious Diseases 1 (2011), 87-92. doi:10.5799/jmid2011.03.0022


MLA (The Modern Language Association) Style

Fetiye Kolaylı, Cansu Semiz, Haluk Vahaboğlu. "In-vitro activity of oxymino-cephalosporins with and without sulbactam against Class A Extended-spectrum β-lactamase producing E.coli." Journal of Microbiology and Infectious Diseases 1.3 (2011), 87-92. Print. doi:10.5799/jmid2011.03.0022


APA (American Psychological Association) Style

Fetiye Kolaylı, Cansu Semiz, Haluk Vahaboğlu (2011) In-vitro activity of oxymino-cephalosporins with and without sulbactam against Class A Extended-spectrum β-lactamase producing E.coli. Journal of Microbiology and Infectious Diseases, 1 (3), 87-92. doi:10.5799/jmid2011.03.0022


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Journal of Microbiology and Infectious Diseases

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