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2025, Vol: 15, Issue: 1
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Research Article 


Deficiency in Fat Soluble Vitamins A, D, E in Patients with Pulmonary Multidrug-resistant Tuberculosis

Boyvin Lydie, Bahi Gnogbo Alexis, Yaye Yapi Guillaume, Seri Kipre Laurent, Ake Aya Jeanne Armande.


Abstract
Objective: The treatment management of Multidrug-Resistant Tuberculosis (MDR-TB) is a major global public health problem. The development of this form of tuberculosis increases immune deficiency and the production of free radicals in the body. Micronutrients, especially fat-soluble vitamins A, D, and E, play an essential role in the immune system by protecting and renewing cells. The objective of this study is to determine the profiles of vitamins A, D, and E in order to evaluate the performance of the immune defenses of MDR-TB under second-line anti-TB treatment.
Methods: The analysis of vitamins A, D and E was carried out using an HPLC chain, in isocratic mode by UV-Visible detection after prior extraction of the lipid fraction from the serum in the hexane protected away from light.
Results: MDR-TB showed a significant decrease in the concentration of vitamins A, D, and E (p˂0.05) with high reduction levels of 80%, 40% and 50%, respectively.
Conclusion: The persistence of this deficit after six months of TB treatment highlights the need for corrective measures to be taken, such as the supplementation of vitamins A, D, and E. J Microbiol Infect Dis 2020; 10(4):199-207.

Key words: Micronutrients, Multidrug-resistant, Tuberculosis, HPLC, Côte d 'Ivoire


 
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How to Cite this Article
Pubmed Style

Lydie B, Alexis BG, Guillaume YY, Laurent SK, Armande AAJ. Deficiency in Fat Soluble Vitamins A, D, E in Patients with Pulmonary Multidrug-resistant Tuberculosis. J Microbiol Infect Dis. 2020; 10(4): 199-207 . doi:10.5799/jmid.839440

Web Style

Lydie B, Alexis BG, Guillaume YY, Laurent SK, Armande AAJ. Deficiency in Fat Soluble Vitamins A, D, E in Patients with Pulmonary Multidrug-resistant Tuberculosis. https://www.jmidonline.org/?mno=302656991 [Access: April 10, 2025]. doi:10.5799/jmid.839440

AMA (American Medical Association) Style

Lydie B, Alexis BG, Guillaume YY, Laurent SK, Armande AAJ. Deficiency in Fat Soluble Vitamins A, D, E in Patients with Pulmonary Multidrug-resistant Tuberculosis. J Microbiol Infect Dis. 2020; 10(4): 199-207 . doi:10.5799/jmid.839440


Vancouver/ICMJE Style

Lydie B, Alexis BG, Guillaume YY, Laurent SK, Armande AAJ. Deficiency in Fat Soluble Vitamins A, D, E in Patients with Pulmonary Multidrug-resistant Tuberculosis. J Microbiol Infect Dis. (2020), [cited April 10, 2025]; 10(4): 199-207 . doi:10.5799/jmid.839440


Harvard Style

Lydie, B., Alexis, . B. G., Guillaume, . Y. Y., Laurent, . S. K. & Armande, . A. A. J. (2020) Deficiency in Fat Soluble Vitamins A, D, E in Patients with Pulmonary Multidrug-resistant Tuberculosis. J Microbiol Infect Dis, 10 (4), 199-207 . doi:10.5799/jmid.839440


Turabian Style

Lydie, Boyvin, Bahi Gnogbo Alexis, Yaye Yapi Guillaume, Seri Kipre Laurent, and Ake Aya Jeanne Armande. 2020. Deficiency in Fat Soluble Vitamins A, D, E in Patients with Pulmonary Multidrug-resistant Tuberculosis. Journal of Microbiology and Infectious Diseases, 10 (4), 199-207 . doi:10.5799/jmid.839440


Chicago Style

Lydie, Boyvin, Bahi Gnogbo Alexis, Yaye Yapi Guillaume, Seri Kipre Laurent, and Ake Aya Jeanne Armande. "Deficiency in Fat Soluble Vitamins A, D, E in Patients with Pulmonary Multidrug-resistant Tuberculosis." Journal of Microbiology and Infectious Diseases 10 (2020), 199-207 . doi:10.5799/jmid.839440


MLA (The Modern Language Association) Style

Lydie, Boyvin, Bahi Gnogbo Alexis, Yaye Yapi Guillaume, Seri Kipre Laurent, and Ake Aya Jeanne Armande. "Deficiency in Fat Soluble Vitamins A, D, E in Patients with Pulmonary Multidrug-resistant Tuberculosis." Journal of Microbiology and Infectious Diseases 10.4 (2020), 199-207 . Print. doi:10.5799/jmid.839440


APA (American Psychological Association) Style

Lydie, B., Alexis, . B. G., Guillaume, . Y. Y., Laurent, . S. K. & Armande, . A. A. J. (2020) Deficiency in Fat Soluble Vitamins A, D, E in Patients with Pulmonary Multidrug-resistant Tuberculosis. Journal of Microbiology and Infectious Diseases, 10 (4), 199-207 . doi:10.5799/jmid.839440


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