E-ISSN 2146-9369 | ISSN 2146-3158
 
2024, Vol: 14, Issue: 4
14 / 4Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles

Research Article 


Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience

Amresh Kumar Singh, Anand Kumar Maurya, Manoj Kumar, Surya Kant, Ram Awadh Singh Kushwaha, Vijaya Lakshmi Nag, Tapan N Dhole.


Cited By:3

Abstract
Objective: Extensively drug-resistant tuberculosis (XDR-TB) strains were emerged when multidrug-resistant TB (MDR-TB) was inadequately treated. Inadequate treatment of MDR-TB cases may result in additional resistance especially non-XDR-TB and then XDR-TB. The aim of this study was to know the prevalence, resistance patterns and trends of the XDR-TB strains among the MDR-TB at a tertiary care hospital in Lucknow, India
Methods: A total of 430 Mycobacterium isolates were underwent NAP test and TB MPT64 Ag test for the identification of Mycobacterium tuberculosis complex (MTBC). Drug-susceptibility test (DST) was performed over MTBC for the first line drugs by 1% proportion method (Bactec) and for the second-line drugs by 1% proportion method (Lowenstein-Jensen media). The XDR-TB status was further confirmed by line probe assay (GenoType® MTBDRsl assay).
Results: Among the 430 isolates of mycobacterium, 365 (84.9%) were MTBC and 139 (38.1%) were MDR-TB respectively. Further 97 MDR-TB from ”highly suspected drug resistant-TB (DR-TB)” cases among MDR-TB were tested with second line drugs in which 15 (15.5%) XDR-TB and 82 (84.5%) were non-XDR-TB. Regarding XDR-TB status, using the 1% proportion method a 100% agreement was seen with the GenoType® MTBDRsl assay. Resistance patterns of XDR-TB were as; 10/15 (66.7%) as isoniazid + rifampicin + ciprofloxacin + amikacin resistance and 5/15 (33.3%) as isoniazid + rifampicin + ciprofloxacin + amikacin + kanamycin resistance.
Conclusion: The prevalence of XDR-TB was 15.5% among MDR-TB. Hence laboratory testing of ”highly suspected drug resistant-TB” isolates should be done for both first and second line drugs simultaneously especially in developing countries. J Microbiol Infect Dis 2013; 3(4): 87-90


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Amresh Kumar Singh
Articles by Anand Kumar Maurya
Articles by Manoj Kumar
Articles by Surya Kant
Articles by Ram Awadh Singh Kushwaha
Articles by Vijaya Lakshmi Nag
Articles by Tapan N Dhole
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Singh AK, Maurya AK, Kumar M, Kant S, Kushwaha RAS, Nag VL, Dhole TN. Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience. J Microbiol Infect Dis. 2013; 3(4): 169-175 . doi:10.5799/jmid2013.04.0103

Web Style

Singh AK, Maurya AK, Kumar M, Kant S, Kushwaha RAS, Nag VL, Dhole TN. Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience. https://www.jmidonline.org/?mno=302656964 [Access: January 09, 2025]. doi:10.5799/jmid2013.04.0103

AMA (American Medical Association) Style

Singh AK, Maurya AK, Kumar M, Kant S, Kushwaha RAS, Nag VL, Dhole TN. Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience. J Microbiol Infect Dis. 2013; 3(4): 169-175 . doi:10.5799/jmid2013.04.0103


Vancouver/ICMJE Style

Singh AK, Maurya AK, Kumar M, Kant S, Kushwaha RAS, Nag VL, Dhole TN. Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience. J Microbiol Infect Dis. (2013), [cited January 09, 2025]; 3(4): 169-175 . doi:10.5799/jmid2013.04.0103


Harvard Style

Singh, A. K., Maurya, . A. K., Kumar, . M., Kant, . S., Kushwaha, . R. A. S., Nag, . V. L. & Dhole, . T. N. (2013) Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience. J Microbiol Infect Dis, 3 (4), 169-175 . doi:10.5799/jmid2013.04.0103


Turabian Style

Singh, Amresh Kumar, Anand Kumar Maurya, Manoj Kumar, Surya Kant, Ram Awadh Singh Kushwaha, Vijaya Lakshmi Nag, and Tapan N Dhole. 2013. Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience. Journal of Microbiology and Infectious Diseases, 3 (4), 169-175 . doi:10.5799/jmid2013.04.0103


Chicago Style

Singh, Amresh Kumar, Anand Kumar Maurya, Manoj Kumar, Surya Kant, Ram Awadh Singh Kushwaha, Vijaya Lakshmi Nag, and Tapan N Dhole. "Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience." Journal of Microbiology and Infectious Diseases 3 (2013), 169-175 . doi:10.5799/jmid2013.04.0103


MLA (The Modern Language Association) Style

Singh, Amresh Kumar, Anand Kumar Maurya, Manoj Kumar, Surya Kant, Ram Awadh Singh Kushwaha, Vijaya Lakshmi Nag, and Tapan N Dhole. "Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience." Journal of Microbiology and Infectious Diseases 3.4 (2013), 169-175 . Print. doi:10.5799/jmid2013.04.0103


APA (American Psychological Association) Style

Singh, A. K., Maurya, . A. K., Kumar, . M., Kant, . S., Kushwaha, . R. A. S., Nag, . V. L. & Dhole, . T. N. (2013) Resistance patterns and trends of extensively drug-resistant tuberculosis: 5-year experience. Journal of Microbiology and Infectious Diseases, 3 (4), 169-175 . doi:10.5799/jmid2013.04.0103


Author LoginReviewer LoginAbout PublisherOpen Access PolicyEditorial PoliciesPeer Review PolicyPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About Journal of Microbiology and Infectious Diseases

Journal of Microbiology and Infectious Diseases (JMID) is an international "peer review" journal in microbiology, infectious diseases, virology, ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes

Editor-in-Chief

Journal of Microbiology and Infectious Diseases

Department of Microbiology and Parasitology 

Faculty of Veterinary Medicine

University of Tripoli

P.O. Box 13662, Tripoli, Libya